DSIP (Delta-Sleep Inducing Peptide). Research Guide

Description of DSIP:

• Empirical formula – C₃₅H₄₈N₁₀O₁₅
• Molecular weight – 848.81
• Amino acid sequence – Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH

Other names:

• DSIP
• Sleep inducing peptide
• TSC22D3
• Glucocorticoid-Induced Leucine Zipper
• Emideltide
• GILZ
• Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
• TSC22 Domain Family Protein 3
• Human Delta-Sleep Inducing Peptide

Discovery:

The Swiss Schoenenberger-Monnier group initially discovered delta-sleep-inducing peptides from the cerebral venous blood of rabbits in an induced state of sleep in 1974. It was thought to play a role in sleep regulation because of its capacity to produce slow-wave sleep in rabbits, but research on the subject has been mixed.

After its initial discovery, scientists discovered DSIP peptide in the human hypothalamus, pituitary gland, limbic system, body fluids, tissues, body, and peripheral organs. DSIP is also common in secretory cells in the stomach and pancreas, interacting with the glucagon hormone.

Mechanism of action:

DSIP is a neuromodulator and peptide that has been investigated for its sleep-promoting and physiological activities in the body. DSIP is a protein that naturally arises in the brain and may easily cross the BBB (blood-brain barrier).

It can have a direct favorable effect on the brain and entire body when it crosses the BBB to:

• Manage stress-related issues and symptoms
• Take care of your body’s aches and pains
• Address issues with insomnia and poor sleep

To induce sleep, DSIP can target multiple brain sites. The effects of enzymes do not denature this peptide, and it is easily absorbed in the human gut. DSIP has a beneficial effect on human circadian rhythm regulation. This peptide is found in low concentrations in the bodies of patients suffering from depression and schizophrenia.

Clinical application:

• Role of DSIP in Sleep:

Scientists have been investigating the effects of this peptide on humans since its discovery. According to a study, DSIP is an effective treatment for sleep disorders. Other than sedatives, DSIP is a sleep-promoting drug. DSIP alters the problematic area of the brain to manage the sleeping cycle, rather than just inducing sleep like sedative drugs. Moreover, Drug tolerance or resistance is not caused by DSIP. As compared to other sleep medications, DSIP dosages are always safer

• Role of DSIP and Convulsive activity:

According to a study, the DSIP peptide can moderate or reduce convulsive activity in the cerebral cortex and foci after delivery. DSIP can help to avoid convulsions by influencing the substantia nigra (reticular part) to act as an anti-convulsant.

• Role of DSIP and hormones:

DSIP coexists alongside different non-peptide and peptide mediators in the pituitary gland, such as ACTH (adrenocorticotrophic hormone), CLIP (corticotropin-like intermediate peptide), TSH (thyroid-stimulating hormone), MCH (melanin-concentrating hormone), and MSH (melanin-stimulating hormone) (melanocyte-stimulating hormone). The regulation and production of human endocrine glands can be improved with DSIP treatment. This peptide has the unique ability to raise the quantity of desired hormones and decrease the number of undesirable hormones.

Disclaimer

The data provided in this article about DSIP peptide has been written to provide knowledge for research advancement. It mainly aims to provide the best information to the emerging researchers who plan to study the benefits and effects of DSIP peptide. The article is specifically designed to provide information about DSIP rather than giving instructions about the use of DSIP. Furthermore, there has been no mention of the route of administration or dosage of the DSIP peptide. The information provided in the article has been collected from different published researchers by a group of expert researchers keeping the medical protocols in view.

Furthermore, this article does not contain any information that will encourage the readers to consume or advertise DSIP peptide. We do not condone any advertisement of any supplement or drug that the FDA has not approved. Melanotan Express insists that no product should be ingested under any circumstances.

References:

• Article title: Delta-sleep-inducing peptide/ Website: Wikipedia URL: https://en.wikipedia.org/wiki/Delta-sleep-inducing_peptide
• Vgontzas, Alexandros N., et al. “Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy.” Peptides 16.6 (1995): 1153-1156.
• Bondarenko, T. I., et al. “Mechanism of geroprotective action of delta-sleep inducing peptide.” Advances in Gerontology 1.4 (2011): 328-339.
• Roy, Koustav, et al. “Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude.” Life sciences 209 (2018): 282-290.
• Hrnčić, Dragan, et al. “Modulatory effects of delta sleep-inducing peptide in a lindane model of generalized seizures.” Archives of Biological Sciences 70.3 (2018): 559-566.
• Amini, Ahmad, et al. “Identification of Peptides and Proteins in Illegally Distributed Products by MALDI-TOF-MS.” Mass Spectrometry in Life Sciences and Clinical Laboratory (2021): 27.

Where to Buy DSIP?

Melanotan Express offers DSIP for sale with at least 99% purity. If you are looking to purchase DSIP Peptide for research purposes, visit Melanotan Express, one of the leading suppliers of the USA SARMS and peptides for sale online:

https://www.melanotanexpress.com/product/dsip-5mg/