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Epithalamion is a natural polypeptide that is typically produced in the pineal gland of the bovine. Epithalon or Epitalon is the synthetic analog of this natural polypeptide.
Chemical Nature of Epithalon 
The chemical formula of the Epithalon is C14H22N4O9.C2H4O2. The amino acid sequence of epithalon is H-Ala-Glu-Asp-Gly-OH.
Other Names  Â
Epithalon is represented by several names, which include Epitalon, Epitalon acetate, monoacetate, and L-alanyl-L-a-glutamyl-L-a-aspartyl-glycine.
How was Epitalon discovered?
Epithalon was first discovered by Professor Vladimir Khavinson. Some colleagues of Professor Vladimir also participated in his research. Dr. Ward Dean was the most significant figure who participated in the discovery of Epithalon after Professor Vladimir. The research of Professor Vladimir and Dr. Ward Dean was published in 1992. The published work of peers was later implemented to humans by V. Khavinson. It was found that Epithalon affects the body on the cellular level. It plays a vital role in the removal of unhealthy cells and increases the life span.
Mechanism of Action
Epitalon is basically a tetrapeptide consisting of four polypeptide chains. Epitalon is also known as the “fountain of youth” peptide. It regulates the cell cycle by regulating the activity of the telomerase enzyme. The telomerase consists of proteins and RNA. The telomerase or telomere terminal transferase enzyme causes the elongation of the terminal part of chromosomes. With the passage of age, the telomeres start to get shorter and reduce in number due to the reduced activity of the telomerase enzyme. The ultimate result of reduced telomerase activity is the shortening of chromosomes which leads to cellular aging.
The primary mechanism by which Epithalon acts is to increase the proliferation and differentiation of telomerase enzyme. Increased activity of the natural telomerase enzyme results in cell rejuvenation and cell division, leading to new cells formation. The quality of cell replication and health depends on the length of chromosomal telomeres. A reduced length of telomeres and reduced telomerase enzyme activity are the main reason for aging and hormonal imbalance such as hypopituitarism or hyperpituitarism. As younger people have longer telomeres, they have comparatively better cell health and cell division.
Clinical Applications of Epitalon
1: Increased life quality and life span
According to some animal studies, Epitalon is beneficial for increasing the life quality and life span. Epitalon is efficient in preventing chromosomal aberrations in the cells of bone marrow. According to a study, the risk of leukemia development reduces by six folds by administration of Epitalon. According to another study, people treated with Epitalon had around 13 percent increase in their life span compared to the control group. Additionally, Epitalon can treat several conditions without imposing any significant side effects on the body.
2: Anti-tumor Activity
According to a controlled research study, Epitalon treatment can cause a significant reduction in the size and number of tumors. It was observed that the Epitalon-treated had reduced metastasis of lung cancer as compared to the control group (Those who were not treated with Epitalon).
Epitalon also inhibits tumor production at the genetic level. It inhibits the expression of specific genes that are involved in the production of adenocarcinoma in mammary glands. According to some researches, it also inhibits programmed cell death or necrosis in the body.
Free radicals are the main reason for tissue destruction that leads to premature aging. Epitalon has a potent antioxidant activity and strongly inhibits free radical-mediated tissue injury. The most important antioxidant Epithalon compound present in the epithalon is melatonin. It prevents several medical conditions such as cardiovascular diseases, diabetes mellitus, and neurodegenerative disorders.
Disclaimer
The data provided in this article about Epitalon Peptide has been written to provide knowledge for the research purposes only. The article is specifically designed to provide information about Epithalon rather than giving instructions about the use of Epithalon. Furthermore, there has been no mention of the route of administration or dosage of the Epitalon. The information provided in the article has been collected from different published researchers by a group of expert researchers keeping the medical protocols in view.
Furthermore, this article does not contain any information to encourage readers to consume or advertise Epithalon. We do not condone any advertisement of any supplement or drug that the FDA has not approved. Melanotan Express insists that no product should be ingested under any circumstances.
References
- https://pubmed.ncbi.nlm.nih.gov/12937682/
- https://pubmed.ncbi.nlm.nih.gov/14501183/
- https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.10570
- https://link.springer.com/article/10.1007/s10522-009-9249-8
- Anisimov VN, Khavinson VKh, Popovich IG and Zabezhinski MA (2002a) Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. Cancer Lett 183: 1-8
- Khavinson VKh, Izmailov DM and Obukhova LK (2000) Effect of Epithalon on the lifespan increase in Drosophila melanogaster. Mech Ageing Dev 120: 141-149
- Khavinson VKh, Goncharova ND and Lapin BA (2001a) Synthetic tetra peptide Epitalon restores disturbed neuroendocrine regulation in senescent monkeys. Neuroendocrinol Lett 22: 251-254
Where to Buy Epitalon Peptide?
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