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Product information:
Chemical formula – C78H111N21O19
Molecular weight – 1646.8
Other names:
- Melanotan I
- Melanotan-1
- 4-Nle-7-phe-alpha-msh
- CUV1647
- UNII-QW68W3J66U
- UNII-QW68W3J66U
- CUV 1647
- 75921-69-6
- QW68W3J66U
- CUV-1647
Discovery of Melanotan 1
Alpha MSH was initially discovered and structurally determined in the 1950s. After this, many scientists tried to develop another potent form of Alpha MSH. The initial form of Melatonan I was discovered in the 1980s at the University of Arizona. Melatonan was named so because it could tan the skin even after minimum exposure.
In 2010, Melatonan I entered Phase III trials to treat erythropoietic protoporphyria. It was approved by the FDA in October 2019 for pain reduction treatment due to light exposure.
Mechanism of Action
Melatonan I is the synthetic form of tridecapeptide. It is also the structural analog of the alpha-melanocyte stimulating hormone. This compound works as a melanocortin receptor agonist. The primary mechanism of action of Melatonan I is that it works by binding to MCI-R. Activation of MCI-R signals also helps in the initiation of several protective processes. These include an increase in the antioxidant activity and repair of DNA. Additionally, it helps in the secretion of immunomodulatory proteins.
Clinical Applications of Melanotan -1 :
The most common indications include:
Vitiligo
Vitiligo is a skin condition in which patients lose melatonin from their skin. Because of this condition, the patients may develop white patches on different body parts. This disease may be triggered due to chemicals or even stress. When administered, a combination therapy of Melatonan I and NB-UV-B monotherapy helps reduce the apparent vitiligo. This therapy helps in improving the vitiligo area scoring index within 2 to 3 months. It also helps in faster repigmentation of the skin.
Erythropoietic Protoporphyria
Erythropoietic Protoporphyria is a very rare and painful disorder in which patients suffer from pain after exposure to the sun. It is because of impairment in an enzyme called ferrochelatase. Melanotan helps in increasing the production of melanin within the skin. An implant of Melatonan helps in reducing pain after exposure to sunlight or an artificial light source.
Acne Vulgaris
Acne Vulgaris is an inflammatory condition of the skin that is characterized by lesions of the skin. Since Melatonan 1 has anti-inflammatory properties, scientists experimented on the results of this compound on acne. After using Melatonan 1, all lesions were reduced in the experiment subjects. Therefore, it can also be concluded that Melatonan1 helps treat patients with mild to moderate cases of acne vulgaris.
Disclaimer
The data provided in this article about the Melanotan 1 peptides has been written to provide knowledge for the research advancement. The article is specifically designed to provide information about the Melanotan 1 rather than giving instructions about the use of it. Furthermore, there has been no mention of the route of administration or dosage of the Melanotan. The information provided in the article has been collected from different published researchers by a group of expert researchers keeping the medical protocols in view.
Furthermore, this article does not contain information that will encourage the readers to consume or advertise Melanotan 2. We do not condone any advertisement of any supplement or drug that the FDA has not approved. Melanotan Express insists that no product should be ingested under any circumstances.
References:
- Pubchem|C78H111N21O19|ncbi.nih.gov| Link: https://pubchem.ncbi.nlm.nih.gov/compound/16154396
- https://www.fda.gov/news-events/press-announcements/fda-approves-first-treatment-increase-pain-free-light-exposure-patients-rare-disorder
- DB04931 | C78H111N21O19| go.drugbank| Link: https://go.drugbank.com/drugs/DB04931
- Lim, Henry W., et al. “Afamelanotide and narrowband UV-B phototherapy for the treatment of vitiligo: a randomized multicenter trial.” JAMA dermatology 151.1 (2015): 42-50.
- https://clinicaltrials.gov/ct2/show/NCT01605136
- Böhm, M., J. Ehrchen, and T. A. Luger. “Beneficial effects of the melanocortin analogue Nle4‐D‐Phe7‐α‐MSH in acne vulgaris.” Journal of the European Academy of Dermatology and Venereology1 (2014): 108-111.
Where to buy Melanotan 1?
Melanotan Express offers Melanotan for Sale with at least 99% purity. If you are buying Melanotan 1 for research purposes, visit Melanotan Express, one of the leading suppliers of the USA Peptides and SARMS for sale: https://www.melanotanexpress.com/product/melanotan-1-mt-1/