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MK-677 is a highly potent secretagogue of growth hormone (GH) . MK-677 is an analog of the endogenous hormone ghrelin, which has a growth hormone stimulating action. Thus, MK-677 mimics the growth hormone secretagogue action of ghrelin, MK-677 has also been shown to increase the secretion of several hormones other than growth hormone, such as insulin-like growth factor 1. MK-677 does not affect the secretion of prolactin and cortisol.
Different Names of MK-677
- Oratrope
- L-163,191
- Ibutamoren mesylate
- UNI-RN0JB6QJ2B
- Crescendo
Chemical Features
The MK-677 is a ghrelin analog with a molecular weight of 624.8g. The molecular formula of MK-677 is C28H40N4O8S2.
Discovery of MK-677Â Â Â Â Â Â Â
Merck initially developed MK-677 in 1995 in the United States of America.
The first beneficial effect of MK-677 identified was its growth hormone secretagogues activity. The formulations of MK-677 have much better growth hormone secretagogues activity than other alternatives used for this purpose. The MK-677 has proven itself the best alternative of growth hormone replacement in people with growth hormone insufficiency. A novel nucleus (Spiroindoline) of MK-677 gained by reduction-based/Fischer indole strategy enhances its activity.
How does MK-677 work?
MK-677 or Ibutamoren is a non-peptide compound. It has highly potent, selective, and long-acting agonist activity at the ghrelin receptors that mimics the action of internal secretagogues of the growth hormone. Increased secretion of growth hormone subsequently causes the release of many other hormones.
MK-677 also has a potent activity of prolonging the activation of growth hormone and insulin-like growth hormone 1. By increasing the release of growth hormone and prolonging its activation duration, MK-677 increases lean body mass without affecting visceral fat.
Proposed Applications and Clinical trials of MK-677
- Reversal of Diet-Induced Catabolism
The trial studies carried on the effects of MK-66 showed the following results.
- MK-77 has a positive effect on nitrogen balance if appropriately used for seven days. MK-677 reverses the wastage of nitrogen that is induced by diet. Hence, it can be used to treat short-term anabolic disease.
- After a five-day trial study with an appropriate dosage of MK-677, there is an increase in the mean of insulin-like growth factor binding proteins.
  2. Clinical trials for Treatment of Obesity
After the clinical studies about the benefits of MK-677 in treating obesity, the following results were gained.
- There is a more than 40 percent increase in the blood concentration of Insulin-like growth factors.
- Among the IGFs, the serum level of IGF-1 was much higher as compared to other IGFs.
- The body gets a leaner shape with a reduction in the amount of fat.
Another two months of clinical research concluded with an almost similar statement. According to the conclusion of that research, after treatment with MK-677, an increase in the anabolic rate of the body was observed. There is an abrupt rise in the basal metabolism, which increases the body’s lean and muscular mass without causing fat accumulation. There is a need for research to evaluate whether a high dose of the MK-677 will have long-term positive effects on the body’s metabolism.
  3. Sleep Quality Research
According to results of another research, there is improvement in the pattern and quality of sleep after treatment with MK-677. The study reveals up to a 50 percent increase in the duration of stage-4 of sleep after treatment with MK-677. There is also a 20 percent increase in REM sleep after the use of MK-677.
Disclaimer
The data provided in this article about MK-677 has been written to provide knowledge for research purposes only. It mainly aims to provide the best information to the emerging researchers who plan to study the benefits and effects of MK-677. The article is specifically designed to provide information about MK-677 rather than giving instructions about the use of MK-677. Furthermore, there has been no mention of the route of administration or dosage of the MK-677. The information provided in the article has been collected from different published researchers by a group of expert researchers keeping the medical protocols in view.
Furthermore, this article does not contain any information that will encourage the readers to consume or advertise MK-677. We do not condone any advertisement of any supplement or drug that the FDA has not approved. Melanotan Express insists that no product should be ingested under any circumstances.
References
Jacks T, Smith R, Judith F, Schleim K, Frazier E, Chen H, et al. MK-0677, a potent, novel, orally active growth hormone (GH) secretagogue: GH, insulin-like growth factor I, and other hormonal responses in beagles. Endocrinology. 1996;137:5284–5289. [PubMed]
Chapman IM, Pescovitz OH, Murphy G, Treep T, Cerchio KA, Krupa D, et al. Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates GH/insulin-like growth factor-I axis in selected GH-deficient adults. J Clin Endocrinol Metab. 1997;82:3455–3463. [PubMed]
.Svensson J, Ohlsson C, Jansson JO, Murphy G, Wyss D, Krupa D, et al. Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males. J Bone Miner Res. 1998;13:1158–1166. [Google Scholar]
Chapman IM, Bach MA, Van Cauter E, Farmer M, Krupa D, Taylor AM, et al. (December 1996). “Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects”. The Journal of Clinical Endocrinology and Metabolism
https://en.wikipedia.org/wiki/Ibutamoren
Bennett PA, Thomas GB, Howard AD, Feighner SD, van der Ploeg LH, Smith RG, et al. Hypothalamic growth hormone secretagogue-receptor (GHS-R) expression is regulated by growth hormone in the rat. Endocrinology. 1997;138:4552–4557. [Google Scholar]
Where to Buy MK 677?
Melanotan Express offers MK-677 for sale with at least 99% purity. If you are looking to purchase MK 677 for research purposes, visit Melanotan Express, one of the leading suppliers of the USA SARMS and peptides for sale online:
Different Names of MK-677
- Oratrope
- L-163,191
- Ibutamoren mesylate
- UNI-RN0JB6QJ2B
- Crescendo