Description of BPC 157
The abbreviation BPC represents the term “Body Protecting Compound.”
The molecular formula of the body-protecting compound is C62-H98-N16-O22.
According to its molecular formula, BPC contains 98 atoms of hydrogen and 62 atoms of carbon. It also contains 16 atoms of nitrogen and 22 atoms of oxygen.
Chemical Structure of BPC 157
The molecular formula of BPC is C62-H98-N16-O22 which has a molecular weight of 1419.5355 g. The nucleotide sequence for BPC is GEPPPGKPADDAGLV.
Other Names of BPC 157
BPC is also known as PL 14736, UNII-8ED8NXK95P, the body protecting compound 15, and BPC 15.
Discovery of BPC 157?
BPC contains a partial body-protecting compound sequence of 15 amino acids. BPC 157 was first discovered from the human body. It was separated from the gastric juice, which contains the enzymes to digest the food in the stomach. Later on, it was found that BPC 157 is exceptionally beneficial to boost the wound healing process. It also accelerates the healing of ruptured tendons such as the Achilles tendon.
Mechanism of Action of BPC 157
BPC is taken either orally or subcutaneously. Irrespective of the route of intake, it reaches the circulation and then to the site of injury. The particular movement of BPC 157 towards the injury site is driven by some specific signaling molecules released from the body’s injured tissue.
Some effects of BPC on the injured tissue that have been observed are in the following section.
1: Effect on FAP-paxillin Pathway
BPC 157 affects the focal adhesion kinase pathway, also called the FAP-paxillin pathway. The focal adhesion kinase enzyme is released at the site of damage by injured tissue.
2: Increased Activity of VEGF
When a tissue regenerates after an injury, there is a need for increased blood supply. A growth factor called vascular endothelial growth factor (VEGF) is released to increase the blood flow to the injured tissue. This VEGF causes angiogenesis or the formation of new blood vessels. BPC 157 is implicated in increasing the release and action of VEGF.
By increasing the VEGF activity, BPC increases the nutrient supply of regenerating tissue. The ultimate result is faster healing of wounds and ruptured tendons. This feature makes BPC 157 an excellent product for situations where there is a need to heal, repair or regrow the body tissues.
3: Upregulation of Growth Hormones
There is an extensive need for collagen synthesis during wounds and ruptured tendons because these structures contain collagen in them. BPC 157 causes upregulation of different growth hormones, leading to increased synthesis of collagen and other proteins. This subsequently results in faster healing of wounds and ruptures.
4: Nitric oxide Production
BPC 157 also increases the production of nitric oxide that causes dilation of existing blood vessels at the injury site. This vasodilation increases the blood supply of the injured tissue.
Clinical Applications of BPC 157
1: Brain-gut Axis and BPC 157
According to some researches, BCP 175 can act as a cytoprotection mediator. This helps in maintaining the integrity of the mucosa of the gastrointestinal tract. According to some controlled experimental studies, BPC 157 can be helpful in the treatment of periodontitis and lesions of the pancreas and liver.
2: Neuroprotective Application
BPC 157 can help in the treatment of dopamine and serotonin-related behavioral disorders. It balances the activity of these neurotransmitter systems on both extremes. It helps in the treatment of damaged as well as overstimulated neurotransmitter systems. There are several other Neuroprotective functions of BPC 157, which include :
- Regeneration of peripheral nerves
- Protection from necrosis of neurons
- Protection against demyelination of axons
- Protection from spinal compression
- Maintaining the integrity of the somatosensory system
3: Tendon and Muscle Healing
Several animal studies show that BPC 157 exponentially fastens the repair of ruptured tendons such as Achilles tendons. Similar animal trials show that BPC can cause tissue regeneration in muscles after crush or cut injury. In animals, the treatment with corticosteroids slowed the healing of wounds. The administration of BPC 157 along with corticosteroids canceled out their wound healing hindrance effect.
The data provided in this article about the BPC-157 peptide has been written to provide knowledge for the research advancement. The article is specifically designed to provide information about the BPC-157 rather than giving instructions about the use of BPC-157. Furthermore, there has been no mention of the route of administration or dosage of the BPC-157. The information provided in the article has been collected from different published researchers by a group of expert researchers keeping the medical protocols in view.
Furthermore, this article does not contain information that will encourage the readers to consume or advertise BPC-157. We do not condone any advertisement of any supplement or drug that the FDA has not approved. Melanotan Express insists that no product should be ingested under any circumstances.
- Jelovac N., Sikiric P., Rucman R., Petek M., Marovic A., Perovic D., Seiwerth S., Mise S., Turkovic B., Dodig G., Miklic P., Buljat G., Prkacin I. Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats. J. Pharmacol. 1999;379(1):19–31.
- Tohyama Y., Sikirić P., Diksic M. Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain: alpha-methyl-L-tryptophan autoradiographic measurements. Life Sci. 2004;76(3):345–357.
- Duplancic B., Stambolija V., Holjevac J., Zemba M., Balenovic I., Drmic D., Suran J., Radic B., Filipovic M., Blagaic A.B., Brcic L., Kolenc D., Grabarevic Z., Seiwerth S., Sikiric P. Pentadeca peptide BPC 157 and anaphylactoid reaction in rats and mice after intravenous dextran and white egg administration. J. Pharmacol. 2014;727:75–79
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