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Product information:
Chemical formula – C46H56N12O6
Molecular weight – 873.0
Other Names:
- UNII-4H7N4I6X6A
- GH-Releasing hexapeptide 6
- CHEMBL105462
- 4H7N4I6X6A
- DTXSID30904007
- ZINC150344347
- NCGC00167341-01
- L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-Lysinamide
Discovery of GHRP-6
Bowers et al. were behind the discovery of a group of compounds that are synthetically produced. These compounds were identified far before scientists had identified the growth releasing hormone (GHRH). The synthetic substances were created from a molecule, metenkephalin, with the help of theoretical calculations. GHRP-6 is a powerful peptide hormone that was originally discovered in the 1980s. The small peptides produced due to these experiments could induce a weak growth hormone release. These scientists then further induced chemical changes. All of these chemical processes led to the discovery of more potent compounds.
Mechanism of Action
The pituitary gland releases hormones that control the secretion of growth hormones. These hormones are released in response to different stimuli, including infusions of growth hormone releasing hormone and somatotropin release inhibiting factor. The basic mechanism of action of growth hormone releasing hexapeptide (GHRP-6) is the stimulation of growth hormone secretion. This is observed in human as well as animal species. However, scientists have not been able to figure out the exact mechanism of action. Certain experiments indicate that GHRP-6 modulates the release of GHH and somatostatin at hypothalamic and pituitary levels.
Clinical Applications of GHRP-6:
The most common indications include:
Multiple Organ Failure
One of the newer therapies for treating multi-organ failure includes synthetic GHRP-6. One certain experiment showed that GHRP-6 helped increase the rate of cell migration by three times. However, cell proliferation was not affected. Additionally, there were quite different results in vivo. In such a case, GHRP-6 reduced intestinal damage, neutrophilic infiltration, and lipid peroxidation by 50-85%. This effect of GHRP-6 was modified when it was combined with EGF.
Wound Healing
A hypertrophic scar is a wound that is thick and raised. This usually happens when the body produces an abnormal response by producing extra connective tissues in the wounded area. Hypertrophic scar leads to a disfigured and aesthetically unpleasing look for the person. The general treatment recommended is Triamcinolone acetonide (TA), the steroid of choice in this case. However, researchers have studied the antifibrotic effects of GHRP-6.
GHRP-6 helps in the prevention of parenchymal fibrotic induration. Furthermore, it also helps in removing the fibrotic material that was accumulated.
Fat loss and muscle growth
GHRP-6 helps in the stimulation of food intake and muscle gain. In an experiment, rats who received GHRP-6 helped in controlling hyperglycemia, hyperphagia, polydipsia, and weight loss.
Rats with diabetes who were administered GHRP-6 gained muscle and fat mass. An increase in serum leptin levels was observed in the rats. Administering insulin with GHRP-6 helps in creating an additive effect. This particular application is very useful for diabetic patients.
Disclaimer:
The data provided in this article about GHRP-6 has been written to provide knowledge for the research purposes only. The article is specifically designed to provide information about GHRP-6 rather than giving instructions about the use of it. Furthermore, there has been no mention of the route of administration or dosage of the GHRP6. The information provided in the article has been collected from different published researchers by a group of expert researchers keeping the medical protocols in view.
Furthermore, this article does not contain any information to encourage readers to consume or advertise GHRP6. We do not condone any advertisement of any supplement or drug that the FDA has not approved. Melanotan Express insists that no product should be ingested under any circumstances.
References:
- https://pubchem.ncbi.nlm.nih.gov/compound/9919153
- https://mayoclinic.pure.elsevier.com/en/publications/ghrelin-a-history-of-its-discovery
- Lengyel, Ana Maria J. “From growth hormone-releasing peptides to ghrelin: discovery of new modulators of GH secretion.” Arquivos Brasileiros de Endocrinologia & Metabologia 50 (2006): 17-24.
- Cibrián, Danay, et al. “Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure.” Clinical science 110.5 (2006): 563-573.
- MarÃ, Yssel Mendoza, et al. “Growth hormone-releasing peptide 6 enhances the healing process and improves the esthetic outcome of the wounds.” Plastic Surgery International 2016 (2016).
- Granado, Miriam, et al. “The positive effects of growth hormone-releasing peptide-6 on weight gain and fat mass accrual depend on the insulin/glucose status.” Endocrinology 151.5 (2010): 2008-2018.
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