- Molecular formula – C17H11N5
- Molecular mass – 285.30 g/mol
- CGS 20267
In the initial years of 1980, researchers from the Swiss company Novartis AG (previously known as Ciba-Geigy AG) did their research work to discover letrozole. During the discovery of letrozole, researchers were working on the identification of the ability of aromatase inhibition. In the initial phases, letrozole had a potent indication for the treatment of breast cancer (estrogen or hormone-dependent breast cancer) in menopausal women. In the recent past, most cancer patients had to undergo surgeries, radiotherapy, or chemotherapy as the first line of treatment for their breast cancer. Now, letrozole is available in tablet form to give an alternative to these options.
Mechanism of action:
Letrozole is a nonsteroidal, type-2 aromatase inhibitor drug which results in the blockage of CYP19A1 and its active sites. This letrozole inhibition helps in preventing the androgen to estrogen conversion. Letrozole action causes specific uterine weight reduction and luteinizing hormone elevation. In postmenopausal women, estrogen production is typically due to aromatase action. With less availability of estrogen, these cancers or tumors tend to decrease in frequency.
Ovarian cancer and anti-estrogen therapy:
In females, ovarian cancer is the fifth most common cause of morbidity and mortality. Most of the time, patients take different treatments such as chemotherapy, debulking, and median progression-free survival (PFS). Different endocrine therapies are proven to be invaluable for the treatment of metastatic breast cancers.
Letrozole is proven to be a potent aromatase inhibitor which rapidly suppresses the estrogen circulating in the body. With the use of letrozole, there are almost no potential risks of partial cancer remission in patients. According to the research evidence, in comparison to other hormonal therapies, letrozole is superior for the treatment of ovarian cancer.
Fertility in females:
Initially, letrozole was developed for ovulation induction as a potential drug. According to different research studies, letrozole has benefits for ovulation induction in women who are suffering from intrauterine insemination, clomiphene citrate resistance, and polycystic ovarian syndrome. Letrozole is also effective for the mild stimulation of in-vitro fertilization and intra-cytoplasmic sperm injection protocols. Letrozole is the by far best option due to its oral consumption, fewer side effects, and shorter half-life.
The data provided in this article about Letrozole has been written to provide knowledge for the research purposes only. The article is specifically designed to provide information about Letrozole rather than giving instructions about the use of it. Furthermore, there has been no mention of the route of administration or dosage of the Letrozole. The information provided in the article has been collected from different published researchers by a group of expert researchers keeping the medical protocols in view.
Furthermore, this article does not contain any information to encourage readers to consume or advertise Letrozole. We do not condone any advertisement of any supplement or drug that the FDA has not approved. Melanotan Express insists that no product should be ingested under any circumstances.
- Letrozole | Compound| Pubchem| Link: https://pubchem.ncbi.nlm.nih.gov/compound/Letrozole
- Letrozole | DB01006| Pubchem| Link: https://go.drugbank.com/drugs/DB01006\
- Bhatnagar, A. S. (2007). The discovery and mechanism of action of letrozole. Breast cancer research and treatment, 105(1), 7-17.
- Yang, A. M., Cui, N., Sun, Y. F., & Hao, G. M. (2021). Letrozole for female infertility. Frontiers in Endocrinology, 12, 737.
- Long, B. J., Jelovac, D., Handratta, V., Thiantanawat, A., MacPherson, N., Ragaz, J., … & Brodie, A. M. (2004). Therapeutic strategies using the aromatase inhibitor letrozole and tamoxifen in a breast cancer model. Journal of the National Cancer Institute, 96(6), 456-465.
- Jee, B. C., Ku, S. Y., Suh, C. S., Kim, K. C., Lee, W. D., & Kim, S. H. (2006). Use of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles: a pilot study. Fertility and sterility, 85(6), 1774-1777.
Where to find Letrozole for Sale?
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