Description of Sermorelin
Sermorelin acetate is the shortest form of a synthetic polypeptide with the same biological activity as growth hormone-releasing hormone. Sermorelin is a polypeptide of 29 amino acids, basically a synthetic analog of growth hormone-releasing hormone. The 29 amino acids of sermorelin represent the 1-29 amino acid fragment of the endogenous human GHRH. Sermorelin is used to assess the amount of growth hormone that is secreted from the pituitary gland. By determining the amount of GH released from the pituitary gland, growth hormone deficiency can be diagnosed with the help of sermorelin peptide.
The structural similarity of the sermorelin with GHRH also increases the release of growth hormones. Hence, it is also used to increase the growth rate in stunted children. Sermorelin can be used as a single medication or with other medicines to increase the growth rate.
Chemical Structure of Sermorelin
Different Names of Sermorelin
- Sermorelin (INN)
- Sermorelin acetate
- GHRH 1-29 amide
- L00266 (2)
- Somatoliberin amide
How was Sermorelin Discovered?
Sermorelin was developed initially in the united states of America between 1970_1980. FDA approved the proper prescription of the sermorelin in 1977. In the initial period, the primary use of the sermorelin was to diagnose growth hormone deficiency (3). Later on, its use for increasing growth hormone production in children with stunted growth was also considered by researchers.
Sone other clinical trials were also carried out on sermorelin to find out its other possible uses. It was also studied for use in muscle wasting in older adults due to a deficiency of growth hormone. Its use in HIV-associated lipodystrophy was also clinically evaluated. Some clinical trials of sermorelin in older adults with cognitive impairment were also considered. (4)
Mechanism of Action
Because Sermorelin is an analog of growth hormone-releasing hormone, it mimics growth hormone-releasing hormone. It binds to the receptors of GHRH present on the growth hormone-releasing cells of the pituitary gland. After attaching these receptors, Sermorelin cause biological activation of these receptors, leading to their second messenger system activation. The ultimate result of activating GHRH receptors and their second messenger system is the increased growth hormone release from the pituitary gland. (5)
Because Sermorelin is an analog of GHRH, it does not interfere with the other pituitary gland cells that do not have the receptors of GHRH. After binding the receptors of GHRH, it causes the release of growth hormone in the same manner as GHRH.
Clinical Applications of Sermorelin
- Treatment of Adult-onset GH Insufficiency
As your age increases, the production of growth hormones from the pituitary gland is reduced. Growth hormone plays a significant role in the growth and maintenance of almost all parts of the body. Hence, an insufficiency of growth hormone occurring with aging leads to muscle wasting and a fragile body built up.
The use of Sermorelin is a practical approach to cope with adult-onset growth hormone insufficiency. Growth hormone is the analog of GHRH and stimulates the GHRH receptors. The activation of these receptors will subsequently lead to increased transcription of human growth hormone messenger RNA. Increased production of growth hormone increases the pituitary reserve of the growth hormone. This reserve of growth hormone helps to prevent muscle wasting and other signs of aging. (6)
Sermorelin also helps in pituitary recrudescence. Pituitary recrudescence causes slowing down of the hypophyseal hormone failure cascade. This mechanism of Sermorelin helps in preserving the normal anatomy and physiology of the body.
- Treatment of Recurrent Glioma
Glioma is a tumor of the CNS( brain or spinal cord) that begins from the supporting glial cells. A treatment insensitivity of a glioma leads to its frequent recurrence. According to the research statistics, Sermorelin treatment has been beneficial in cases of recurrent glioma. The Sermorelin helps in recurrent glioma by inhibiting the proliferation of tumor cells in their cell cycle. Sermorelin also affects the function of the immune system, which plays a role in tumor progression. It has a negative regulatory effect on the M0 macrophages. It also affects the working of immune checkpoints. (7)
3. Cardiovascular Health
A study about the benefit of Sermorelin in the survival of cardiac myocytes was carried out on animals. According to that study, the Sermorelin enhances the survival of cardiac myocytes through activation of protective mechanisms against I/R injury. The results of this study are equally applicable to humans. (8)
The data provided in this article about Sermorelin has been written to provide knowledge for research purposes only. The article is specifically designed to provide information about Sermorelin rather than giving instructions about the use of Sermorelin. Furthermore, there has been no mention of the route of administration or dosage of the Sermorelin. The information provided in the article has been collected from different published researchers by a group of expert researchers keeping the medical protocols in view.
Furthermore, this article does not contain any information that will encourage the readers to consume or advertise Sermorelin. We do not condone any advertisement of any supplement or drug that the FDA has not approved. Melanotan Express insists that no product should be ingested under any circumstances.
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